Micky van de Ven Double Ends The Toffees' Run at New Stadium
Micky van de Ven became the initial backline player to net twice in a English top-flight match for Spurs since the Belgian defender in March 2013.
Match summary
Micky Van de Ven nods into the net twice in first half
The home side's Jake O'Brien has goal ruled after VAR review
Pape Matar Sarr scores third in 89th minute
This loss is the Merseyside club's first at their new ground
Micky van de Ven found the net twice as Tottenham extended their winning streak on the road in the top division and delivered Everton their initial loss at Hill Dickinson Stadium.
Everton were unbeaten in their last five matches at their recently opened stadium at Bramley-Moore Dock, having left Goodison Park behind after 133 years at the conclusion of last season.
But Spurs captain the Dutchman pounced on two occasions from set-pieces in the opening 45 minutes to place their impressive record at jeopardy, and they were unable to turn it around before Pape Matar Sarr - assisted by former Toffees attacker the Brazilian - nodded in a final goal to put the game to bed.
The Everton defender believed he had equalized the scores a short while after the defender's opener, glancing a bullet header past Guglielmo Vicario from an Everton corner.
Beto, meanwhile, failed to convert a number of chances, while the Italian goalkeeper made a series of fine saves to ensure the London club went five matches on the road unbeaten in the Premier League.
But the video assistant referee intervened, instructing the match official to review the goal on the pitchside monitor and the official decided that the winger and the attacker were in an illegal position and had impeded with the Spurs keeper.
This victory elevates the manager's team up to third in the division, five points off local foes and table-toppers Arsenal.
Everton remain in 14th position and are six points clear of the relegation zone.
Spurs breakdown: Van de Ven fulfils duties at each end of pitch
Following a drab weekday performance in the Champions League against the French side, where they mustered a mere attempts on target, the manager chose Randal Kolo Muani in attack instead of former Toffees player Richarlison.
The summer signing was unable to influence the game before being substituted for the substitute after 60 minutes on the pitch, but it emerged he proved unnecessary in the end.
Centre-back Van de Ven converted into an attacking force to be reckoned with.
Tottenham's first goal came from a well-worked set-piece play, with the midfielder heading the ball back across the face of goal for an free the defender to head home.
And Ven de Ven - stepping up as skipper in the Argentine's absence - notched his second in first-half stoppage time as he rose above Jordan Pickford to nod in.
The Dutchman was equally outstanding in defence, partnering effectively with his defensive colleague as the duo dealt superbly with the numerous deliveries thrown their way by Everton.
Everton analysis: Toffees missing finishing touch
Everton's recent stadium had been a fortress, but it seems the freshness may have worn off somewhat and fans headed to the gates after the midfielder's final goal for Spurs.
The break in Everton's winning streak at home won't be a massive concern for the manager, but their attacking woes will be.
Beto and the other striker - the Toffees' two recognised centre-forwards - had netted only one league goal between them before Sunday's match.
And they were unable to contribute to that miserable record on a damp and dreary evening on Merseyside.
The striker's performance was epitomized when he chose to overhead kick a clear chance from near the goal, even with having room and time to readjust for a simpler attempt that would have tested Vicario.
Barry, too, was unable to influence the game after coming on for Beto in the 65th minute.
It was not for a lack of opportunity. Most of Everton's offensive moves came through the winger and Ndiaye, who tirelessly delivered dangerous balls into the Tottenham box.
What next for both teams?
The Toffees: The team head to Sunderland in the Premier League on Monday, 3 November at 8 PM.
Tottenham: The London club go to St James' Park on Wednesday, 29 October for their next round Carabao Cup tie against the Magpies.